Journal Title：Journal Of Gene Medicine

The aims and scope of The Journal of Gene Medicine include cutting-edge science of gene transfer and its applications in gene and cell therapy, genome editing with precision nucleases, epigenetic modifications of host genome by small molecules, siRNA, microRNA and other noncoding RNAs as therapeutic gene-modulating agents or targets, biomarkers for precision medicine, and gene-based prognostic/diagnostic studies.

Key areas of interest are the design of novel synthetic and viral vectors, novel therapeutic nucleic acids such as mRNA, modified microRNAs and siRNAs, antagomirs, aptamers, antisense and exon-skipping agents, refined genome editing tools using nucleic acid /protein combinations, physically or biologically targeted delivery and gene modulation, ex vivo or in vivo pharmacological studies including animal models, and human clinical trials.

Papers presenting research into the mechanisms underlying transfer and action of gene medicines, the application of the new technologies for stem cell modification or nucleic acid based vaccines, the identification of new genetic or epigenetic variations as biomarkers to direct precision medicine, and the preclinical/clinical development of gene/expression signatures indicative of diagnosis or predictive of prognosis are also encouraged.

The Journal of Gene Medicine 的目标和范围包括基因转移的前沿科学及其在基因和细胞治疗中的应用、使用精确核酸酶进行基因组编辑、通过小分子、siRNA、microRNA 等对宿主基因组进行表观遗传修饰非编码 RNA 作为治疗性基因调节剂或靶标、精准医学的生物标志物以及基于基因的预后/诊断研究。

感兴趣的关键领域是新型合成和病毒载体的设计、新型治疗性核酸（如 mRNA、修饰的 microRNA 和 siRNA）、拮抗剂、适体、反义和外显子跳跃剂、使用核酸/蛋白质的精细基因组编辑工具组合、物理或生物靶向递送和基因调节、离体或体内药理学研究，包括动物模型和人体临床试验。

论文介绍了基因药物的转移和作用机制、干细胞修饰或核酸疫苗新技术的应用、新的遗传或表观遗传变异作为生物标志物的鉴定以指导精准医学，以及还鼓励对指示诊断或预测预后的基因/表达特征进行临床前/临床开发。