Journal Title：Cancer Biology & Therapy

Cancer, the second leading cause of death, is a heterogenous group of over 100 diseases. Cancer is characterized by disordered and deregulated cellular and stromal proliferation accompanied by reduced cell death with the ability to survive under stresses of nutrient and growth factor deprivation, hypoxia, and loss of cell-to-cell contacts. At the molecular level, cancer is a genetic disease that develops due to the accumulation of mutations over time in somatic cells. The phenotype includes genomic instability and chromosomal aneuploidy that allows for acceleration of genetic change. Malignant transformation and tumor progression of any cell requires immortalization, loss of checkpoint control, deregulation of growth, and survival. A tremendous amount has been learned about the numerous cellular and molecular genetic changes and the host-tumor interactions that accompany tumor development and progression. It is the goal of the field of Molecular Oncology to use this knowledge to understand cancer pathogenesis and drug action, as well as to develop more effective diagnostic and therapeutic strategies for cancer. This includes preventative strategies as well as approaches to treat metastases. With the availability of the human genome sequence and genomic and proteomic approaches, a wealth of tools and resources are generating even more information. The challenge will be to make biological sense out of the information, to develop appropriate models and hypotheses and to translate information for the clinicians and the benefit of their patients. Cancer Biology & Therapy aims to publish original research on the molecular basis of cancer, including articles with translational relevance to diagnosis or therapy. We will include timely reviews covering the broad scope of the journal. The journal will also publish op-ed pieces and meeting reports of interest. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats. The journal and the outstanding Editorial Board will strive to maintain the highest standards for excellence in all activities to generate a valuable resource.

癌症是导致死亡的第二大原因，是由 100 多种疾病组成的异质组。癌症的特征是细胞和基质增殖紊乱和失调，伴随着细胞死亡减少，能够在营养和生长因子剥夺、缺氧和细胞间接触丧失的压力下生存。在分子水平上，癌症是一种遗传疾病，是由于体细胞中突变随时间累积而发展起来的。表型包括基因组不稳定性和允许加速遗传变化的染色体非整倍性。任何细胞的恶性转化和肿瘤进展都需要永生化、检查点控制的丧失、生长失调和存活。大量的细胞和分子遗传变化以及伴随肿瘤发展和进展的宿主-肿瘤相互作用已经被了解。分子肿瘤学领域的目标是利用这些知识来了解癌症发病机制和药物作用，以及开发更有效的癌症诊断和治疗策略。这包括预防策略以及治疗转移的方法。随着人类基因组序列以及基因组和蛋白质组学方法的可用性，大量工具和资源正在产生更多信息。挑战将是从信息中获得生物学意​​义，开发适当的模型和假设，并为临床医生和患者的利益翻译信息。癌症生物学与治疗旨在发表关于癌症分子基础的原创研究，包括与诊断或治疗具有转化相关性的文章。我们将包括涵盖期刊广泛范围的及时评论。该杂志还将发表评论文章和感兴趣的会议报告。目标是通过使用传统和电子格式及时发布重要结果来促进信息交流和快速交流。期刊和杰出的编辑委员会将努力在所有活动中保持最高标准，以产生宝贵的资源。